Adult Stem Cell Therapy Blog

Adult Stem Cell Research at UB Targets Damaged Hearts

Tuesday, June 13, 2006 - Stem Cell Guru

Many of the stories online regarding grants being awarded for stem cell research may appear to relate to embryonic cell research and often only loose promises of funding rather than hard cash.

However, the University at Buffalo, USA, has recently received a $1.98 million grant from National Institutes of Health to investigate the potential of bone marrow-derived adult stem cells to treat the serious heart malfunction known as hibernating myocardium.

Hibernating myocardium is a condition in which heart cells that have experienced reduced blood flow over an extended period of time due to narrowed coronary arteries adapt to this deprivation by down-regulating metabolism while remaining functionally viable.

Previous work in UB's Center for Cardiovascular Research has shown that restoring normal blood flow to these "hibernating" regions improves function. However, these results also found that cells in the left ventricle, the heart's main pumping chamber, often do not return to normal, leaving the heart compromised.

Researchers will investigate whether transplanting the model's own bone marrow mesenchymal stem cells (MSC), cells that have the capacity to develop into blood vessels, as well as other types of tissues can change the myocardial adaptive responses and improve the function of the hibernating myocardium.

The full story can be found on the University at Buffalo website.


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